Promethazine and codeine should be used throughout pregnancy only if the probable advantage justifies the possible hazard on the fetus.
Excessively massive dosages of antihistamines, such as promethazine hydrochloride, in pediatric individuals may perhaps induce unexpected Dying (see OVERDOSAGE). Hallucinations and convulsions have transpired with therapeutic doses and overdoses of promethazine hydrochloride in pediatric patients. In pediatric sufferers who will be acutely sick connected with dehydration, there is a heightened susceptibility to dystonias with using promethazine HCl.
Anaphylactic reactions, as adjunctive therapy to epinephrine and also other standard measures, following the acute manifestations happen to be managed.
Pregnancy Checks: Diagnostic pregnancy tests according to immunological reactions among HCG and anti-HCG may well result in false-unfavorable or Untrue-beneficial interpretations.
For preoperative medication kids demand doses of 0.five mg per pound of body fat in combination with the correctly reduced dose of narcotic or barbiturate and the suitable dose of an atropine-like drug.
Focus–Adverse Response Associations You will find there's marriage concerning rising codeine plasma focus and escalating frequency of dose- relevant opioid adverse reactions for instance nausea, vomiting, CNS results, and respiratory melancholy.
Sedation This product relieves apprehension and induces a silent snooze from which the affected individual might be conveniently aroused.
Kids Postmarketing instances of respiratory despair, including fatalities, are read more documented with usage of promethazine in pediatric individuals. Concomitant administration with other respiratory depressants could boost the chance of respiratory despair.
Labor or Shipping Opioids cross the placenta and may make respiratory melancholy and psycho-physiologic consequences in neonates. An opioid antagonist, such as naloxone, have to be accessible for reversal of opioid-induced respiratory despair during the neonate.
Excessively huge dosages of antihistamines, like Promethazine HCl Oral Option, in pediatric people may well bring about sudden Demise (see OVERDOSAGE). Hallucinations and convulsions have occurred with therapeutic doses and overdoses of Promethazine in pediatric people. In pediatric patients who're acutely ill connected to dehydration, There exists an elevated susceptibility to dystonias with the usage of Promethazine HCl.
Be sure that patients have an oral dosing dispenser that measures the appropriate quantity in milliliters. Counsel people on how to utilize an oral dosing dispenser and properly measure the oral suspension as prescribed.
Neuroleptic malignant syndrome (NMS) which may result in death. Inform you Health care provider at once if you have any of the following indicators of NMS:
Codeine was not mutagenic inside the in vitro bacterial reverse mutation assay or clastogenic while in the in vitro Chinese hamster ovary (CHO) cell chromosomal aberration assay.
Avoid the use of Promethazine HCl and Codeine Phosphate Oral Solution in adolescents 12 to eighteen years of age who produce other possibility things that will boost their sensitivity to the respiratory depressant effects of codeine. Threat components include problems related to hypoventilation, such as postoperative status, obstructive rest apnea, weight problems, extreme pulmonary sickness, neuromuscular condition, and concomitant usage of other medicines that result in respiratory depression.